Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy.
by Steimer W, Zöpf K, von Amelunxen S, Pfeiffer H, Bachofer J, Popp J, Messner B, Kissling W, Leucht S.
Affliation: Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. W.Steimer@gmx.de
Journal: Clin Chem. 51(2):376-85
Publication Date: Monday, January 31, 2005
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In vitro ADME phenotyping in drug discovery: current challenges and future solutions.
by Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L, Sahi J.
Affliation: Pfizer Global Research and Development, Pharmacokinetics, Dynamics and Metabolism, Ann Arbor, MI 48103, USA. james.williams2@pfizer.com
Journal: Curr Opin Drug Discov Devel. 8(1):78-88
Publication Date: Monday, January 31, 2005
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Potential role of drug transporters in the pathogenesis of medically intractable epilepsy.
by Kwan P, Brodie MJ.
Affliation: Division of Neurology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. patrickkwan@cuhk.edu.hk
Journal: Epilepsia. 46(2):224-35
Publication Date: Monday, January 31, 2005
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The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation.
by de Leon J, Susce MT, Pan RM, Fairchild M, Koch WH, Wedlund PJ.
Affliation: University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA. jdeleon@uky.edu
Journal: J Clin Psychiatry. 66(1):15-27
Publication Date: Wednesday, January 26, 2005
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Pharmacogenomics and systems biology of membrane transporters.
by Yan Q.
Affliation: MedImmune, Inc., 297 N. Bernardo Ave., Mountain View, CA 94043.
Journal: Mol Biotechnol. 29(1):75-88
Publication Date: Tuesday, January 25, 2005
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Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1).
by Barrero FJ, Ampuero I, Morales B, Vives F, de Dios Luna Del Castillo J, Hoenicka J, García Yébenes J.
Affliation: 1Movement Diseases Unit, University Hospital of San Cecilio, Granada, Spain.
Journal: Pharmacogenomics J. :
Publication Date: Tuesday, January 25, 2005
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Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1.
by Huang Y, Blower PE, Yang C, Barbacioru C, Dai Z, Zhang Y, Xiao JJ, Chan KK, Sadée W.
Affliation: 1Department of Pharmacology, Comprehensive Cancer Center, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA.
Journal: Pharmacogenomics J. :
Publication Date: Tuesday, January 25, 2005
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Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2.
by Hiroi T, Wei H, Hough C, Leeds P, Chuang DM.
Affliation: 1Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Journal: Pharmacogenomics J. :
Publication Date: Tuesday, January 25, 2005
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Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers.
by Munafò MR, Johnstone EC, Welsh KI, Walton RT.
Affliation: 1Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK.
Journal: Pharmacogenomics J. :
Publication Date: Tuesday, January 25, 2005
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Cytogenetics and gene discovery in psychiatric disorders.
by Pickard BS, Millar JK, Porteous DJ, Muir WJ, Blackwood DH.
Affliation: 1Medical Genetics, School of Molecular and Clinical Medicine, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Journal: Pharmacogenomics J. :
Publication Date: Tuesday, January 25, 2005
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Pharmacogenetics: policy needs for personal prescribing.
by Melzer D, Raven A, Ling T, Detmer D, Zimmern R.
Affliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK.
Journal: J Health Serv Res Policy. 10(1):40-4
Publication Date: Tuesday, January 25, 2005
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Utilization of Human Liver Microsomes to Explain Individual Differences in Paclitaxel Metabolism by CYP2C8 and CYP3A4.
by Taniguchi R, Kumai T, Matsumoto N, Watanabe M, Kamio K, Suzuki S, Kobayashi S.
Affliation: Department of Pharmacology, St. Marianna University School of Medicine.
Journal: J Pharmacol Sci. 97(1):83-90
Publication Date: Monday, January 24, 2005
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Drug evaluation, drug development and pharmacogenetics: celebrating 30 years of progress.
by Li Wan Po A.
Affliation: Centre for Evidence-Based Pharmacotherapy, Aston University, Birmingham, UK.
Journal: J Clin Pharm Ther. 30(1):1-4
Publication Date: Thursday, January 20, 2005
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Advances in childhood leukaemia: successful clinical-trials research leads to individualised therapy.
by Ziegler DS, Dalla Pozza L, Waters KD, Marshall GM.
Affliation: Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital, Randwick, NSW, Australia.
Journal: Med J Aust. 182(2):78-81
Publication Date: Monday, January 17, 2005
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Fundamentals of cancer biology for pharmacogenomics.
by Rosell R.
Affliation: Institut Catal d'Oncologia. Hospital Germans Trias i Pujol, Ctra. Canyet, s/n. 08916 Badalona, Barcelona, Spain.
Journal: Curr Oncol Rep. 6 Suppl 1:S20-2
Publication Date: Monday, January 17, 2005
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Special report: genotyping for cytochrome P450 polymorphisms to determine drug-metabolizer status.
by
Affliation:
Journal: Technol Eval Cent Asses Program Exec Summ. 19(9):1-2
Publication Date: Friday, January 14, 2005
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Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status.
by Almeida S, Franken N, Zandoná MR, Osório-Wender MC, Hutz MH.
Affliation: 1Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Journal: Pharmacogenomics J. 5(1):30-4
Publication Date: Thursday, January 13, 2005
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[Pharmacogenetics: Important aspects for dermatology.]
by Merk HF.
Affliation: Universität-Hautklinik, Klinik für Dermatologie & Allergologie der RWTH Aachen, .
Journal: Hautarzt. :
Publication Date: Wednesday, January 12, 2005
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Live smallpox experiments may go ahead.
by Senior K.
Affliation:
Journal: Lancet Infect Dis. 5(1):10
Publication Date: Tuesday, January 11, 2005
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PolyMAPr: Programs for polymorphism database mining, annotation, and functional analysis.
by Freimuth RR, Stormo GD, McLeod HL.
Affliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Journal: Hum Mutat. 25(2):110-117
Publication Date: Tuesday, January 11, 2005
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